Which brain region is responsible for secreting gonadotropin-releasing hormone?

• A. Thalamus
• B. Hypothalamus
• C. Anterior pituitary
• D. Posterior pituitary

Answer: (B)

GnRH is produced by neurons in the hypothalamus and released into the hypophyseal portal system to stimulate the anterior pituitary to secrete LH and FSH. The hypothalamus acts as the control center that initiates gonadotropin release; the thalamus mainly handles sensory relay, the anterior pituitary releases hormones but does not make GnRH, and the posterior pituitary stores and releases hormones made in the hypothalamus (like oxytocin and vasopressin). So the region responsible for secreting GnRH is the hypothalamus.