Which statement correctly describes the effect of PTH on phosphate reabsorption in the kidney?

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Study for the NCLEX with quiz on the Endocrine System. Engage with multiple choice questions, detailed explanations, and tips for success. Prepare for your NCLEX exam!

Multiple Choice

Which statement correctly describes the effect of PTH on phosphate reabsorption in the kidney?

Explanation:
Parathyroid hormone reduces phosphate reabsorption in the kidney by acting on the proximal tubule, where it downregulates the sodium–phosphate cotransporters (NPT2a/NPT2c). This lowers phosphate reabsorption and increases its excretion in urine. The distal tubule’s main role under PTH is calcium handling, not phosphate. PTH also increases 1,25-dihydroxy vitamin D production, which raises intestinal phosphate (and calcium) absorption. So the key renal effect of PTH on phosphate is a proximal-tubule–mediated phosphaturic action.

Parathyroid hormone reduces phosphate reabsorption in the kidney by acting on the proximal tubule, where it downregulates the sodium–phosphate cotransporters (NPT2a/NPT2c). This lowers phosphate reabsorption and increases its excretion in urine. The distal tubule’s main role under PTH is calcium handling, not phosphate. PTH also increases 1,25-dihydroxy vitamin D production, which raises intestinal phosphate (and calcium) absorption. So the key renal effect of PTH on phosphate is a proximal-tubule–mediated phosphaturic action.

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